Failed Ketamine Antidepressant Could Help in Opioid Addiction

 

A few months ago it was announced that two ketamine-based drugs had been placed on the FDA fast track. One of the drugs, esketamine, has since been approved for treating depression. But the other, rapastinel, failed its late-stage trials for depression treatments.

 

While rapastinel didn’t get approval from the FDA as a depression treatment, it may still be useful in treating opiate addiction. Rapastinel is based on the drug ketamine, but it has proven to have fewer risks than it’s parent drug, which is why it may be helpful in treating opioid addictions.

 

In an animal study, it was found that rapastinal was able to substantially reduce opioid withdrawal symptoms. Withdrawal during the first few days, especially for opiate drugs, can be intense. Physical symptoms can include nausea, vomiting, stomach pain, diarrhea, muscle aches, chills, sweating, fast heart rate, insomnia, and agitation. There can also be psychological symptoms such as depression, aggression, or anxiety.

 

The US is currently in the midst of an opioid epidemic. There are around 36 million people around the world that are abusing opioids. Currently, drugs such as methadone and suboxone are used to treat withdrawal. While these do work, they are still opioid, which increases the risk of abuse.

 

During the animal study, researchers modeled opiate addiction in rats and then tracked their signs of withdrawal. Rats were broken into groups and given rapastinel, ketamine, or a saline solution. On the third day, rats that had received rapastinel showed far fewer withdrawal symptoms than the other rats.

 

Currently, rapastinel is only in the animal testing phase. However, with the trails this promising it’s likely that further studies will be done. With such a severe opiate epidemic going on a new treatment is much needed. While it’s unfortunate that rapastinel isn’t effective as a depression treatment it’s great that researchers have found another use for it.

 

Feel free to contact us to learn more about ketamine for depression treatment, or visit Delray Center for Addiction Medicine to learn about opiate withdrawal.

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Dr. Rodriguez founded the Delray Center in 2003 and built it on a foundation of core clinical, professional, and ethical principles that are adhered to still to this day. Dr. Rodriguez founded the Delray Center in 2003 and built it on a foundation of core clinical, professional, and ethical principles that are adhered to still to this day.